Deputies said they were driving past 770 Deltona Blvd., around 12:30 a.m., Sunday when they saw the car up against a wall at the doctor's office.
The front end of the car was crushed and deputies said they found a man behind the wheel and unresponsive. There was little damage to the building.
The man was extricated from the car and rushed to Florida Hospital Fish Memorial in Orange City where he was pronounced dead.
The identification of the driver was not being released pending notification of next-of-kin, deputies said.
The crash remains under investigation.