ORCHARD PARK, N.Y. -- Sammy Watkins had a career-best 168 yards receiving and a touchdown, and rookie running back Karlos Williams scored twice in leading the Buffalo Bills to a 33-11 win over the Miami Dolphins on Sunday.
Watkins broke the game open with a 44-yard touchdown catch from Tyrod Taylor to put the Bills up 26-14 late in the third quarter. LeSean McCoy had a season-best 112 yards rushing and a touchdown, before leaving in the fourth quarter with a right shoulder injury.
Linebacker Jerry Hughes had two sacks, including a forced fumble, which he recovered to set up Watkins' score.
The Bills (4-4) were coming out of their bye week.
Miami (3-5) continued to regress. Coming off a 36-7 loss to New England, Miami has lost two straight since winning its first two games after interim coach Dan Campbell took over when Joe Philbin was fired.
The Dolphins are 0-4 against AFC East rivals.