It happened at the Lee Motel, located at 201 S. 14th St.
The victim told officers he was inside his room with three women and four children, whom he had just met, at the time of the break-in and robbery.
Police say the man told them he was laying down with his eyes closed when a masked man entered the motel room with a gun.
The victim said he hid inside the bathroom with two of the women, until the suspect broke down the door.
That's when police say the victim was blindfolded, disrobed and tied up, as the suspect asked him "Where's it at?"
The victim told police he didn't know what the the man was talking about or looking for.
A short while later, the victim said the man left with the three women and four children.
The victim's wallet, cellphone and car were also gone.
However, the car was later found abandoned in Groveland.
Police say it's unclear if the three women were involved in the robbery.
Anyone with information is asked to call the Leesburg Police Department at 352-787-2121 or Crimeline at 1-800-423-TIPS.