Police said they accident happened around 2:35 a.m. on the westbound ramp of Interstate 4 at Universal Boulevard.
Officers said when they arrived, they found a car had gotten off Interstate 4 at Universal Boulevard. While taking the elevated ramp, the driver lost control and struck the barrier.
The car went over the barrier, crashing back down on the ramp below. Police said one person was killed and two other people were taken to the hospital with critical injuries.
Police kept the exit closed while they continued their investigation.