Police said the crash happened just before 2:30 a.m., Saturday on State Road 436 near the intersection of Lake Howell Lane.
Investigators said a man was driving southbound when, for some reason, he crossed into the northbound lanes hitting another car. Both people in that car died. Police say the driver of the first car has minor injuries.
All lanes of State Road 436 were shut down overnight, but re-opened just after 6:30 a.m.
Casselberry police said there are no charges at this time, but the investigation is continuing.
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